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Questions (answers at bottom of page):


1. Overview of Hematology


1.1 Which of the following is the result of a mutation of a gene that codes for an enzyme that is responsible for reducing reactive oxygen species in RBCs?
  • a. Pyruvate Kinase Deficiency
  • b. Glucose-6-Phosphate Dehydrogenase Deficiency
  • c. Thalassemia
  • d. Spherocytosis

1.2 Which of the following is not necesary to create a functional RBC?
  • a. B12
  • b. Folic acid
  • c. Iron
  • d. Erythropoietin
  • e. None of the above



2. Blood Cell Types


2.1 What are the following cell types (in order)?
cell1.PNG cell10.PNGcell2.PNGcell6.PNGcell9.PNGcell8.PNGcell7.PNGcell11.PNG
  • a) RBC, Lymphocyte, Platelet, Eosinophil, Monocyte, Neutrophil, Basophil, Band Cell
  • b) Erythrocyte, Lymphocyte, Platelet, Basophil, Monocyte, Band Cell, Eosinophil, Neutrophil
  • c) RBC, Monocyte, Thrombocyte, Basophil, Lymphocyte, Neutrophil, Eosinophil, Band Cell
  • d) Erythrocyte, Lymphocyte, Thrombocyte, Basophil, Monocyte, Neutrophil, Eosinophil, Band Cell

2.2 A count of 800 / μL is within normal limits for which of the following cell types?
  • a. Monocytes
  • b. Neutrophils
  • c. Platelets
  • d. Basophils

2.3 It is not out of the ordinary to find which of the following cells missing entirely from a CBC?
  • a. Neutrophils
  • b. Eosinophils
  • c. Monocytes
  • d. Lymphocytes

3. Overview: From Innate to Adaptive Immunity


3.1 - 3.11 Match the terms with their letters. Answers may used more than one or not at all.
Questions

Answers
3.1 T cell

a. An activated B cell.
3.2 TLR

b. This cell serves as the interface between innate and adaptive immune responses.
3.3 PAMP

c. This molecule of the innate immune system is produced by epithelia and burrows holes pathogen membranes.
3.4 Cathelicidin

d. This is a sub-type of PRR that is homologous to similar receptor in the fruit fly.
3.5 Dendritic Cells

e. This is the mother of all inflammatory transcription factors
3.6 Antigenic Determinant/Epitope

f. Cells of this type may release short range mediators called lymphokines
3.7 NF-κB

g. When activated, cells of this type release antibodies.
3.8 MHC Class II

h. A type of chemokine.
3.9 B Cell

i. A foreign molecule structure that the innate immune system might recognize as being a pathogen.
3.10 Plasma Cell

j. A smaller part of a larger molecule that fits into a lymphocyte's receptor.
3.11 Defensin

k. This is one type of antigen-presenting molecule.

3.12 Which helper T cell helps B cells to get activated so that the B cell may produce IgM, IgG, IgE, and IgA antibodies?
  • a. Th1
  • b. Th17
  • c. Th2
  • d. Tfh
  • d. Treg

3.13 Which of the following T cells has the CD8 molecular marker (which helps in increasing antigen affinity) but does not interact with MHC Class II molecules?
  • a. CTL
  • b. Th1
  • c. Th17
  • d. Th2

3.14-3.18 Match the antibody with its function:
Questions

Answers
3.14 IgG

a. This antibody is a first line defense in tears, saliva, genitourinary fluids, intestinal fluids, and milk.
3.15 IgM

b. This antibody is inserted into B cell membranes as an antigen receptor.
3.16 IgD

c. This antibody is attached to mast cells.
3.17 IgA

d. This is the most abundant antibody in the body and is involved in the complement system. It is the only type of antibody that is passed from mother to fetus.
3.18 IgE

e. This is the first antigen to appear in the blood after exposure to a new antigen. It's replaced by a different antibody a week or two later.


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Answers:


1. Overview of Hematology


1.1 Which of the following is the result of a mutation of a gene that codes for an enzyme that is responsible for reducing reactive oxygen species in RBCs?
  • a. Pyruvate Kinase Deficiency This is a disorder in the glycolytic pathway.
  • b. Glucose-6-Phosphate Dehydrogenase Deficiency
  • c. Thalassemia This is a disorder involving a lack of α or β hemoglobin subunits
  • d. Spherocytosis This is due to a disorder involving cytoskeletal/transmembrane proteins.



2. Blood Cell Types




2.1 What are the following cell types (in order)?
cell1.PNG cell10.PNGcell2.PNGcell6.PNGcell9.PNGcell8.PNGcell7.PNGcell11.PNG
  • a) RBC, Lymphocyte, Platelet, Eosinophil Granules stain red, Monocyte, Neutrophil, Basophil, Band Cell
  • b) Erythrocyte, Lymphocyte, Platelet, Basophil, Monocyte, Band Cell Nucleus connections must be thicker than 1/3 of a lobe to be band cell, Eosinophil, Neutrophil
  • c) RBC, Monocyte, Thrombocyte, Basophil, Lymphocyte This cell has a band-like nucleus and no granules--must be monocyte, Neutrophil, Eosinophil, Band Cell
  • d) Erythrocyte, Lymphocyte, Thrombocyte, Basophil, Monocyte, Neutrophil, Eosinophil, Band Cell

2.2 A count of 800 / μL is within normal limits for which of the following cell types?
  • a. Monocytes
  • b. Neutrophils
  • c. Platelets
  • d. Basophils

2.3 It is not out of the ordinary to find which of the following cells missing entirely from a CBC?
  • a. Neutrophils
  • b. Eosinophils And Basophils
  • c. Monocytes
  • d. Lymphocytes

3. Overview: From Innate to Adaptive Immunity


3.1 - 3.11 Match the terms with their letters. Answers may used more than one or not at all.
Questions

Answers
3.1 T cell
F
a. An activated B cell.
3.2 TLR
D
b. This cell serves as the interface between innate and adaptive immune responses.
3.3 PAMP
I
c. This molecule of the innate immune system is produced by epithelia and burrows holes pathogen membranes.
3.4 Cathelicidin
C
d. This is a sub-type of PRR that is homologous to similar receptor in the fruit fly.
3.5 Dendritic Cells
B
e. This is the mother of all inflammatory transcription factors
3.6 Antigenic Determinant/Epitope
J
f. Cells of this type may release short range mediators called lymphokines
3.7 NF-κB
E
g. When activated, cells of this type release antibodies.
3.8 MHC Class II
K
h. A type of chemokine.
3.9 B Cell
G
i. A foreign molecule structure recognized by the innate immune system as being a pathogen.
3.10 Plasma Cell
A
j. A smaller part of a larger molecule that fits into a lymphocyte's receptor.
3.11 Defensin
C
k. This is one type of antigen-presenting molecule.

3.12 Which helper T cell helps B cells to get activated so that the B cell may produce IgM, IgG, IgE, and IgA antibodies?
  • a. Th1 Inflammatin, lymphokines
  • b. Th17 Similar to Th1 with more powerful inflammation
  • c. Th2 Walls of pathogens, important in parasite immunity
  • d. Tfh aka Follicular Helper T Cells
  • d. Treg Regulates Th1, Th2, & Th17

3.13 Which of the following T cells has the CD8 molecular marker (which helps in increasing antigen affinity) but does not interact with MHC Class II molecules?
  • a. CTL aka Cytotoxic T Cells
  • b. Th1
  • c. Th17
  • d. Th2

3.14-3.18 Match the antibody with its function:
Questions

Answers
3.14 IgG
D
a. This antibody is a first line defense in tears, saliva, genitourinary fluids, intestinal fluids, and milk.
3.15 IgM
E
b. This antibody is inserted into B cell membranes as an antigen receptor.
3.16 IgD
B
c. This antibody is attached to mast cells.
3.17 IgA
A
d. This is the most abundant antibody in the body and is involved in the complement system. It is the only type of antibody that is passed from mother to fetus.
3.18 IgE
C
e. This is the first antigen to appear in the blood after exposure to a new antigen. It's replaced by a different antibody a week or two later.