Chemotherapy+Agents

2. Crosslink DNA || 1. Increased GSH 2. DNA Repair: remove covalent alkyl group from guanine 3. DNA Repair: crosslink repair via nucleotide excision || 1. Hematopoetic tox 2. GI tox/nausea/vomiting 3. Gonadal tox 4. Alopecia 5. Carcinogenesis || 2. In vitro: topoisomerase mutations || 1. Myelosuppresion 2. Anthracyclin: cardiotox 3. Can cause AML ||
 * || MOA || Resistance || Tox ||
 * 1. DNA Alkylating || 1. Covalently bind to DNA
 * 2. Topoisomerase Interacting || 1. Prevents severed DNA from religating || 1. Increased efflux
 * 3. ||  ||   ||   ||